Noroozi M, et al. - Among people who inject drugs (PWID) in Tehran, Iran, experts ascertained the prevalence of injection site skin infections and its associated risk factors. The frequency of injection per day, reuse of their own syringes, not using needle and syringe program (NSP) services, HIV status, socioeconomic status with skin infections in PWID were the several risk factors for injection sites infections among PWID. The focus of prevention strategies to reduce skin infections ought to be on high-risk injection behaviors and improving access to NSP services.