Scully PR, Patel KP, Treibel TA, et al. - Researchers assumed that individuals with dual aortic stenosis and cardiac amyloid pathology (AS-amyloid) would have different baseline characteristics, periprocedural and mortality outcomes. Researchers included individuals aged ≥ 75 with severe aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) at two sites who had undergone blinded bone scintigraphy prior to intervention (Perugini Grade 0 negative, 1–3 increasingly positive). Echocardiography, electrocardiogram (ECG), blood tests, 6-min walk test, and health questionnaire, with periprocedural complications and mortality follow-up were included as baseline assessment. This study enrolled a total of 200 individuals (aged 85 ± 5 years, 50% male). The study's findings demonstrate that AS-amyloid is common and differs from lone AS. The data reveal that in AS-amyloid, transcatheter aortic valve implantation significantly improved outcome, while there were similar periprocedural complications and mortality to lone AS, implying that TAVI should not be denied to individuals with AS-amyloid.