Prevalence and molecular epidemiology characteristics of carbapenem-resistant Escherichia coli in Heilongjiang Province, China
Infection and Drug Resistance Aug 16, 2019
Cheng P, Li F, Liu R, et al. - In this retrospective study, researchers sought to ascertain the prevalence and molecular epidemiology traits of carbapenem-resistant Escherichia coli (CRE). From pigs and urban rivers, they recovered a total of 593 E. coli isolates from 2009 to 2014 in Heilongjiang Province of China; from these, they selected 40 CRE, including 22 strains isolated from fecal samples of pigs and 18 strains isolated from water samples. From water samples, they identified five NDM-1-positive E. coli isolates. As per genetic environment analysis, all of the NDM-1-positive isolates had a cluster of genes (ISAba125-blaNDM-1-bleMBL-ΔtrpF). As per conjugation assays, successful transmission of blaNDM-1 to E. coli J53 from five donor strains was possible at frequencies of 4.6×10−5 to 2.6×10−2. The outcomes suggest a higher overall antimicrobial resistance in E. coli recovered from water samples vs the strains isolated from fecal samples of pigs.
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