Lorthe E, et al. - Researchers sought to describe both perinatal and 2-year outcomes of preterm infants born after preterm premature rupture of membranes at 22-25 weeks’ gestation. In EPIPAGE-2, a French national prospective population-based cohort of preterm infants born in 546 maternity units in 2011, 1,435 women with a diagnosis of preterm premature rupture of membranes were identified. Among these, 379 were at 22-25 weeks’ gestation, with 427 fetuses (331 singletons and 96 twins). Outcomes suggested a high incidence of mortality and morbidity in association with preterm premature rupture of membranes at 22-25 weeks, with wide variations by gestational age at preterm premature rupture of membranes. However, there were a non-negligible proportion of children who survived without severe morbidity both at discharge and at 2-years’ corrected age.