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Preterm delivery and long-term risk of stroke in women: A national cohort and cosibling study

Circulation May 16, 2021

Crump C, et al. - Researchers sought to ascertain risk estimates for stroke and major types of stroke related to preterm delivery in the largest population-based cohort to date. They performed this national cohort study of >2 million women in Sweden, to assess alterations in such risks across the life course with up to 43 years of follow-up. In addition, they inquired about potential confounding by shared genetic or environmental factors in families via conducting cosibling analysis. They found higher future risks of both hemorrhagic and ischemic stroke in relation to preterm delivery, in this large national cohort. These links continued to be substantially increased at least 40 years later, and were identified to be largely independent of covariates and shared familial factors. Preterm delivery should be acknowledged as a factor that confers risk for stroke in females across the life course.

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