Cheung H, et al. - Researchers conducted this retrospective study to examine presumed activated retinal astrocytes and Müller cells (ARAM) detected by scanning laser ophthalmoscopy and spectral domain optical coherence tomography, and to explore its presence in healthy controls as well as its connection to posterior vitreal detachment (PVD) and glaucoma. The sample consisted of 805 controls (1,337 eyes) between ages 8 and 90, and 146 patients (250 eyes) with glaucoma between the ages of 28 and 95. Findings suggested that ARAM can be detected using spectral-domain optical coherence tomography in a clinical setting. PVD appears to be a necessary but not a sufficient factor for the presence of ARAM in both normal and glaucomatous eyes, while the incidence of glaucoma may be higher. It remains unclear what impact ARAM has on glaucoma management.