Qian B, et al. - Researchers investigated the influence of preoperative ultrasound-guided multilevel paravertebral blocks (PVBs) on chronic pain following mastectomy in this prospective, randomized, double-blinded, parallel-group, placebo-controlled trial. They randomized 184 women to receive ultrasound-guided multilevel (T1–T5) PVBs with 5 mL of ropivacaine 0.5% or normal saline per level. Immediate postoperative pain decreased significantly for the first 12 hours with ultrasound-guided multilevel PVBs. At 3 months, the PVB and control groups had the chronic pain (BPI average pain score ≥3) incidence of 34.5% and 51.2%, respectively, and at 6 months, the incidence was 22.1% and 37.2%, respectively. Outcomes thus support the efficacy of perioperative ultrasound-guided multilevel PVBs with ropivacaine for improving acute postoperative pain and decreased postmastectomy chronic pain at 3 and 6 months postoperatively.