Mathis MR, Naik BI, Freundlich RE, et al. - Researchers examined whether preoperative risk influences the correlation between intraoperative hypotension and acute kidney injury. From eight hospitals, they reviewed 138,021 cases who underwent major noncardiac surgical procedures; of these, 12,431 (9.0%) developed postoperative acute kidney injury. Anemia, estimated glomerular filtration rate, surgery type, American Society of Anesthesiologists Physical Status, and expected anesthesia duration were the major risk factors included. Findings revealed varying associations of adult cases undergoing noncardiac surgery demonstrate with distinct levels of hypotension when stratified by preoperative risk factors. An important independent risk factor for acute kidney injury was specific levels of absolute hypotension, but not relative hypotension. Cases with low risk exhibited no associated heightened risk of acute kidney injury across all blood pressure ranges, whereas cases with the highest baseline risk exhibited an association between even mild absolute intraoperative hypotension ranges and acute kidney injury.