Ikeno Y, et al. - Authors sought to determine the clinical prognostic indicators by examining the molecular profiles of intrahepatic cholangiocarcinoma (ICC) and assessing the preoperative imaging data of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET). The enrollment consisted of patients with ICC who underwent curative hepatectomy after ¹⁸F-FDG-PET examination. In patients with ICC, high MTV exhibited a correlation with KRAS mutation and poor postoperative outcomes. Yielded data pointed out that the metabolic tumor volume (MTV) of ICC estimated via ¹⁸F-FDG-PET possibly presented with beneficial information for tumor molecular profiles and prognosis.