Kimura H, et al. - In this investigation involving 104 superficial esophageal squamous cell carcinomas (SESCCs), in which Type B2 was observed by magnifying endoscopy, researchers studied risk factors for misdiagnosis in preoperative invasion depth staging. Based on pathological depth of invasion, SESCCs were classified as either correct diagnosis (pMM/SM1, 39 lesions), overdiagnosis (epithelium or the lamina propria [pEP/LPM], 34 lesions), or underdiagnosis (deep invasion into the submucosa [pSM2-3], 31 lesions). Using logistic regression analysis, the connection between misdiagnosis and endoscopic features, including distinct features [defined as nodular protrusion, thickness, and/or clearly depressed area], was assessed. Using a receiver operating characteristic curve, type B2 area diameter was endoscopically measured and the cut-off value was determined. The findings from the present study suggested that lesions with a small Type B2 area (<6 mm) and/or Type B2 vessels around erosion should be diagnosed as EP/LPM, and lesions with distinct characteristics as SM2-3.