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Preoperative histogram parameters of dynamic contrast-enhanced MRI as a potential imaging biomarker for assessing the expression of Ki-67 in prostate cancer

Cancer Medicine Jun 16, 2021

Zhang Y, Li Z, Gao C, et al. - This study attempted to explore if preoperative histogram parameters of dynamic contrast-enhanced MRI (DCE-MRI) can assess the expression of Ki-67 in prostate cancer (PCa). Researchers enrolled a consecutive series of 76 patients with pathology-proven PCa who had undergone routine DCE-MRI scans. They used Spearman rank correlation analysis to examine the relationship of these parameters and Ki-67 expression of PCa. The study enrolled a total of 88 PCa lesions, including 31 lesions with high Ki-67 expression and 57 lesions with low Ki-67 expression. This study’s findings demonstrate that histogram of DCE-MRI quantitative parameters is correlated with Ki-67 expression, which has the potential to noninvasively assess the expression of Ki-67 with patients of PCa.

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