Zeng M, Dong J, Lin N, et al. - In this single-center, randomized, placebo-controlled, and double-blinded trial, researchers assessed the analgesic impact of gabapentin on postoperative pain relief in 122 patients undergoing elective craniotomy by a suboccipital or subtemporal approach. The participants were randomized to a placebo group (patients received vitamin B) and to gabapentin group (patients received gabapentin (600 mg, orally) the night before surgery and 2 hours before anesthesia induction). A significant reduction in acute postoperative pain was noted in participants who received preoperative gabapentin. Also, it reduced the incidence of vomiting among patients undergoing suboccipital or subtemporal craniotomy. However, gabapentin increased the postoperative sedation score at 2 hours and therefore, early postoperative sedation deserves more attention when multimodal analgesia with gabapentin is given.