Zhu Y, et al. - Clinicopathological and contrast-enhanced CT features of 63 patients with intrahepatic cholangiocarcinomas (ICCs) were investigated to compare the variation of CT characteristics between ICCs with and without lymph node metastasis (LNM) and to build a nomogram to prognosticate LNM and overall survival preoperatively. In clinical symptoms, tumor position, morphologic classification, arterial phase enhancement degree–mean, arterial phase enhancement degree–max, portal venous phase enhancement degree–max, equilibrium phase (EP) enhancement ratio, EP CT value–max, and EP CT value–max/liver, intrahepatic cholangiocarcinomas with and without LNM varied significantly. A nomogram was constructed to prognosticate LNM on the basis of morphologic classification, EP CT value–max, and EP enhancement ratio. Patients with ICC with LNM risk of 0.20 or greater based on the nomogram exhibited a significantly poorer overall survival in comparison with LNM risk less than 0.20. Thus, between those with and without LNM, preoperative CT characteristics of ICCs varied significantly. Nomogram on the basis of those characteristics could prognosticate LNM and overall survival even better than the N stage.