Qu J, Zhang D, Zhang H, et al. - To determine the impact of clopidogrel within 5 days prior to coronary artery bypass grafting (CABG) on outcomes among patients encountering acute coronary syndrome (ACS), researchers undertook this retrospective analysis. Participants were selected from a single center, and included consecutive patients with ACS who had isolated CABG. A composite of death, myocardial infarction, and stroke within 30 days post-surgery was assessed as the primary outcome. CABG-related major bleeding as well as perioperative transfusion constituted secondary outcomes. There were 5,543 patients with ACS in total, of those, 820 (14.8%) continued clopidogrel within 5 days prior to CABG. Findings revealed increased odds of major cardiac and cerebrovascular events as well as bleeding complications in relation to clopidogrel therapy within 5 days before surgery, vs discontinuing clopidogrel for >5 days, in this patient population.