Sun F, et al. - The predictive value of preoperative albumin-to-fibrinogen ratio (AFR), fibrinogen-to-pre-albumin ratio (FPR), fibrinogen (Fib), albumin (Alb), and pre-albumin (pre-Alb) in patients with colorectal cancer (CRC) was examined. For this analysis, 3 years of follow-up was conducted with 702 stage I–III resected CRC subjects diagnosed between January 2008 and December 2013. By X-tile software, Kaplan–Meier curve, and Cox regression model, optimal cutoff points and prognostic values of AFR, FPR, Fib, Alb, pre-Alb, and a novel carcinoembryonic antigen (CEA)-carbohydrate antigen 19-9 (CA199)-FPR (CCF) score were evaluated. The findings from the present study suggested that FPR, as well as CCF score, were promising biomarkers to predict the prognosis of CRC and to classify which stage II–III patients could benefit from adjuvant chemotherapy.