Ikoma N, et al. - Experts investigated if preoperative chemoradiation (CXRT) improved the incidence of primary tumor pathologic complete response (ypT0) and overall survival (OS) compared with preoperative chemotherapy in patients with gastric cancer. Eligible candidates included subjects with non-metastatic gastric adenocarcinoma who underwent CXRT or chemotherapy followed by gastrectomy. Findings illustrated a connection between CXRT with a higher incidence of ypT0 and R0 resection compared with chemotherapy. Nevertheless, it did not appear to be related to a longer OS. It was determined that the safety profiles (30-day mortality, 30-day readmission, and length of hospital stay) were equivalent between groups.