Cao X, Cui J, Li Z, et al. - Whether C-reactive protein/albumin ratio (CAR) has predictive value in gastrointestinal stromal tumors (GISTs), was inquired in this retrospective study. Participants were 325 patients with primary GIST surgically managed with curative intent from 2009 to 2018. The best cut-off point of CAR was defined to be 0.55. Elevated CAR was shown to be related to the location of the lower digestive tract, larger tumor size, higher mitotic index, higher National Institute of Health (NIH) risk classification, lower albumin, higher C-reactive protein, as well as higher Glasgow prognostic score. In this study, CAR was identified as a new independent predictor of poor survival in GIST cases. The combination of CAR and NIH risk classification showed the ability to effectively improve the performance of prognosis prediction.