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Prenatal prognostic factors for isolated right congenital diaphragmatic hernia: A single center’s experience

BMC Pediatrics Oct 27, 2021

Jeong J, Lee BS, Cha T, et al. - The likely applicability of observed-to-expected lung area-to-head circumference ratio (O/E LHR) (a well-characterized prognostic indicator in left-sided congenital diaphragmatic hernia) in patients with antenatally diagnosed right-sided congenital diaphragmatic hernia (RCDH) is indicated in this study. For verification of the link between O/E LHR values and the graded severity of RCDH, a large cohort study is needed.

  • A retrospective review of 39 newborn infants with isolated RCDH; a total of 26 (66.7%) survived to discharge.

  • Survivors had significantly greater O/E LHR (64.7 ± 21.2) vs non-survivors (40.5 ± 23.4).

  • In survivors without extracorporeal membrane oxygenation (ECMO) requirement, O/E LHR was greater (68.3 ± 15.1) vs non-survivors or those with ECMO requirement (46.3 ± 19.4).

  • For mortality prediction in isolated RCDH, the best O/E LHR cut-off value was 50.

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