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Prenatal and postnatal cardiac development in offspring of hypertensive pregnancies

Journal of the American Heart Association May 12, 2020

Aye AYL, Lewandowski AJ, Lamata P, et al. - Given an association of pregnancy complications such as preterm birth and fetal growth restriction with altered prenatal and postnatal cardiac development, researchers here studied if there were changes related specifically to pregnancy hypertension. Echocardiography was performed in 134 term‐born infants for left and right ventricular volumes, mass, and function at birth and 3 months of age. Of these infants, 54 were born to mothers who had normotensive pregnancy and 80 were born to mothers with a diagnosis of preeclampsia or pregnancy‐induced hypertension. Findings yielded evidence of both prenatal and postnatal differences in cardiac development among infants born at term to a hypertensive pregnancy, with right ventricular changes proportional to the severity of the pregnancy disorder. Further study is required to determine if differences persist long term as well as their underlying cause and relationship to increased cardiovascular risk.

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