Prenatal and childhood adversity and inflammation in children: A population-based longitudinal study
Brain, Behavior, and Immunity Feb 10, 2020
Flouri E, et al. - Researchers examined if and how early prenatal events (at 18 weeks pregnancy), childhood events (measured on seven occasions at ages 0-9 years) and their interaction were associated with inflammatory markers [serum C-reactive protein and interleukin 6 (IL-6)] at age 9 years, using a general-population birth cohort (n = 3,915), the Avon Longitudinal Study of Parents and Children. For this purpose, they employed latent growth curve modelling as well as linear regression. Findings revealed a positive association of the number and rise in the number of adverse life events experienced in childhood with plasma levels of inflammatory markers, such as IL-6, in girls, independently of prenatal adverse life events.
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