Breasail MÓ, et al. - Utilizing peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HR-pQCT) techniques between the early second (14-16 weeks) and the third trimester (34-36 weeks) in UK women aged 30-45 years, researchers sought to quantify the extent of pregnancy-induced changes in compartmental (trabecular and cortical) volumetric BMD (vBMD) and bone mineral microarchitecture. According to findings, pregnancy-related reductions in total and compartment-specific vBMD at distal tibia surpass age-related change. Changes at the radius were only apparent with pQCT at the cortical-rich proximal site and indicate endosteal resorption. Although the magnitude of these pregnancy-related changes in the appendicular skeleton is minimal, if they represent global changes across the skeleton at large they may contribute substantially to the Ca requirements of the fetus.