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Pregnancy-related acute kidney injury in preeclampsia: Risk factors and renal outcomes

Hypertension Oct 06, 2019

Conti-Ramsden FI, Nathan HL, De greeff A, et al. - Researchers undertook this prospective observational multicenter study to investigate the incidence of acute kidney injury (AKI), its risk factors, and renal outcomes in women admitted with preeclampsia in South Africa. Using national laboratory databases, they obtained creatinine concentrations for women with maximum creatinine of ≥ 90 μmol/L (≥ 1.02 mg/dL). They used Kidney Disease Improving Global Outcomes creatinine criteria to define renal injury and recovery. AKI criteria were met by 237 (15.3%) of a total of 1,547 women admitted with preeclampsia. Overall, a common incidence of AKI was reported in women with preeclampsia. The presence of AKI was associated with high rates of maternal and perinatal mortality. Confirmed renal recovery was seen in only two-thirds of women. A crucial risk factor was a history of a previous hypertensive pregnancy.
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