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Pregnancy-related acute kidney injury at high altitude: A retrospective observational study in a single center

BMC Nephrology Jun 15, 2021

Li X, Wu X, Zhang M, et al. - Researchers analyzed women living at high altitude to determine incidence, etiology, clinical characteristics as well as maternal-fetal outcomes of pregnancy-related acute kidney injury(Pr-AKI) in this population. Screening for Pr-AKI was performed in 6,512 pregnant females visiting the Department of Obstetrics & Gynecology at a local hospital from January 2015 to December 2018. In 136/6512(2.09 %) patients, Pr-AKI was detected. The main reason for Pr-AKI was hypertensive disorders of pregnancy(HDP). Death occurred in 4(2.9 %) women and the majority(86.1 %) had recovered kidney function prior to discharge. In 30(27.3 %) cases, preterm delivery happened, and perinatal deaths occurred in 17(15.5 %) cases. Findings showed that among women residing at high-altitude regions, occurrence of Pr-AKI was not rare and resulted in severe fetal morbidities and mortalities. The identified risk factors for adverse fetal outcomes in Pr-AKI cases, particularly for patients with HDP, included uncontrolled blood pressure, high altitude and advanced AKI.

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