Kimball AB, Guenther L, Kalia S, et al. - Utilizing data from the Psoriasis Longitudinal Assessment and Registry (PSOLAR), researchers conducted this cohort study to determine if there is an association between pregnancy outcomes and psoriasis or exposure to systemic therapies for moderate-to-severe psoriasis. Data were available for 298 pregnancies in 220 patients (mean [SD] age, 27.8 [5.2] years) who had been enrolled for a median duration of 7.2 (range, 3.3-8.0) years per patient. Rates of spontaneous abortion, neonatal problems, and congenital anomalies were comparable to rates in the general US population, and pregnancy outcomes for women exposed to biologics were comparable to those for women with exposure to nonbiologics. Pregnancy outcomes among women with moderate-to-severe psoriasis in PSOLAR were consistent with previously published data and the general population. To better characterise the relationship between psoriasis and treatment and birth outcomes, pregnancy-specific registries with a greater number of pregnant women with psoriasis than PSOLAR are required.