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Pregnancy outcomes in women after arterial switch operation for transposition of the great arteries: Results from ROPAC (Registry of Pregnancy and Cardiac Disease) of the European Society of Cardiology EURObservational Research Program

Journal of the American Heart Association Jan 08, 2021

Tutarel O, Ramlakhan KP, Baris L, et al. - Researchers sought to describe the pregnancy outcomes in women after an arterial switch procedure for transposition of the great arteries. From the ROPAC (Registry of Pregnancy and Cardiac disease), an international prospective registry of pregnant women with cardiac disease, part of the European Society of Cardiology EURObservational Research Programme. A major adverse cardiovascular event was assessed as the primary end point; it was defined as combined end point of maternal death, supraventricular or ventricular arrhythmias requiring treatment, heart failure, aortic dissection, endocarditis, ischemic coronary events, and thromboembolic events. Among 41 included pregnant women (mean age, 26.7±3.9 years), no maternal mortality was recorded. Overall findings suggest that pregnancy is well tolerated by women after an arterial switch procedure for transposition of the great arteries, with a favorable maternal and fetal outcome. Most women should be reassured during counseling that the risk of pregnancy is low. Classification as modified World Health Organization risk class II appears applicable.

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