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Pregnancy outcome and cost‐effectiveness comparisons of artificial cycle‐prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: A randomized controlled trial

BJOG: An International Journal of Obstetrics and Gynaecology Aug 18, 2020

Luo L, Chen M, Wen Y, et al. - Via performing an open‐label, randomized, controlled trial, researchers sought to compare the live birth rate and cost effectiveness of artificial cycle‐prepared frozen embryo transfer (AC‒FET) with vs without GnRH agonist (GnRH‐a) pretreatment for women with polycystic ovary syndrome (PCOS). Among 343 included women with PCOS (aged 24‒40 years), who were scheduled for AC‒FET and receiving no more than two blastocysts, 172 formed the pretreatment group and received GnRH‐a pretreatment; and 171 formed the control group and did not received GnRH. Outcomes revealed that among women with PCOS receiving AC‒FET, there was no improvement in pregnancy outcomes but significantly increases in patient cost in correlation with pretreatment with GnRH‐a.

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