Wang YX, Mínguez-Alarcón L, Gaskins AJ, et al. - A greater risk of cardiovascular disease (CVD) was observed in relation to pregnancy loss (PL), this was independent of subsequent development of metabolic disorders.

• A study of 95,465 ever-gravid women taking part in the Nurses’ Health Study II between 1993 and 2017.

• During follow-up, a hazard ratio (HR) of 1.21 for CVD was reported in relation to PL, post-adjustment for confounders; a similar link was noted for coronary heart disease (CHD) (HR 1.20) and stroke (HR 1.23).

• Elevation in CVD risk was evident with the number of PLs [HR 1.18 for 1 and 1.34 for ≥2 times].

• CVD risk was greater for PL happening early in reproductive lifespan [HR 1.40 for age ≤23 years, 1.25 for age 24–29 years, and 1.03 for age ≥30 years].

• Factors that explained <1.80% of the connection between PL and CVD included hypertension, hypercholesterolemia, and type 2 diabetes.