Maxwell S, et al. - As the risk of HIV transmission in men who have sex with men (MSM) who experience problematic chemsex could be substantially reduced with using preexposure prophylaxis (PrEP), researchers here sought for the biopsychosocial characteristics that are associated with PrEP use among these HIV-negative MSM. Secondary data collected during client assessments at a specialist alcohol and drug service based within the United Kingdom were analyzed in this cross-sectional analysis. Complete assessment of 165 HIV-negative MSM who engaged in chemsex [median age: 36 years, 92% gay (n = 152/165); 79% of white ethnicity (n = 130/164)] was done from August 2016 to July 2018. Ever use of PrEP was reported in 34% (n = 50/145). Higher levels of men ever using PrEP was observed in correlation to using crystal methamphetamine (40% vs 21%). A higher median number of sexual partners in the previous 3 months (20 vs 10) and a lower level of condom use in the sex lives (median reported 5% vs 50%) were reported in men who had ever used PrEP in comparison to men who had never used PrEP. These findings of accessing PrEP among men having higher-risk sex are encouraging.