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Preeclampsia resolution after fetal death in multifetal gestation: A systematic literature review

American Journal of Obstetrics and Gynecology Jan 24, 2020

Pham A, et al. - Researchers investigated the rate of preeclampsia resolution in multifetal gestation after fetal death, spontaneous or induced via performing a systematic literature review of all published reports of multifetal gestation complicated by preeclampsia with fetal death and assessing two additional cases from their institution. They recognized 14 studies and added 2 case reports from their institution for a total of 19 cases. Prior to or at the time of fetal death, an abnormality in anatomy, fetal growth, amniotic fluid, or umbilical artery Doppler of at least 1 fetus was reported in all 19 cases (100.0%). A high rate of 88% of preeclampsia resolution and a 7 week gain in gestation for the surviving fetus were reported, in this work. Inherent publication bias is the limitation of this study. Expectant management of pregnancies complicated by preeclampsia is potentially associated with serious maternal risks, even after fetal death.
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