Metcalfe KA, Retrouvey H, Kerrebijn I, et al. - In women with unilateral breast cancer without a BRCA1 or BRCA2 mutation, researchers assessed demographic, clinical, and psychosocial predictors of the uptake of contralateral prophylactic mastectomy (CPM). A total of 506 women agreed to participate, 112 of whom chose CPM. Age was found to be a significant predictor of CPM, with younger women found to be much more likely than older women to undergo CPM. Compared with those with invasive breast cancer, the rate of CPM was significantly higher in women with noninvasive breast cancer. Compared with women who did not undergo CPM, women who elected to undergo CPM had lower levels of presurgical breast satisfaction (body image) and optimism. Psychosocial functioning in decision-making on breast cancer surgery affects CPM-related choices. Taking into account psychosocial functioning when discussing surgical options is important for healthcare providers.