Toboni MD, et al. - Researchers investigated the preoperative risk factors associated with unplanned reoperation within 30 days for patients undergoing major surgery for primary ovarian cancer. Via performing a retrospective cohort study utilizing the National Surgical Quality Improvement Program database, they identified that 148 of 4260 patients undergoing primary ovarian cancer surgery from 2012 to 2014 underwent a reoperation within 30 days of their primary surgery. As per the univariate analysis, predictors of a reoperation were preoperative creatinine 1.5 mg/dL or greater, smoking, and both insulin-dependent and non–insulin-dependent diabetes mellitus. The multivariate analysis suggested that predictors of a reoperation were smoking, insulin-dependent diabetes mellitus, non–insulin-dependent diabetes mellitus, and preoperative creatinine. When compared with age younger than 50 years, age 50 to 60 years was identified to be protective against reoperation. Optimization of the medical status prior to surgery with respect to these factors may reduce the reoperation rate in patients with ovarian cancer, thereby improving outcomes and providing a probable cost benefit.