Harcombe H, et al. - Researchers conducted this prospective Subsequent Injury Study investigating preinjury sociodemographic and heath factors, and injury-related factors, that predict subsequent injury claims reported to Accident Compensation Corporation (ACC, New Zealand's universal injury insurer) in the 24 months following an ACC entitlement claim injury (‘sentinel’ injury). They used two separate outcome variables to recognize subsequent injuries of interest: having 1) at least one high severity injury claim (New Injury Severity Scores ≥ 4), or 2) two or more claims (injuries of any severity). Participants with a self-reported prior injury affecting them at the time of their sentinel injury, and those who prior to their sentinel injury event had pain/discomfort, or were physically active on five or more days of the week more frequently suffered severe and multiple ACC-reported subsequent injuries (ACC-SI). A lower likelihood of severe or multiple ACC-SI was more commonly noted among those aged 30-64 years vs those aged 18-29 years, those of ‘other’ ethnicity compared with sole New Zealand European ethnicity, and if the sentinel injury associated hospitalization. For males, and for participants with ≥ 2 chronic conditions vs those with none, a higher likelihood of multiple ACC-SI was observed. This work suggests valuable flags to assist healthcare providers and policymakers recognize people at heightened risk of severe or multiple subsequent injuries who may benefit from targeted injury prevention strategies or interventions.