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Predictors of pathological complete response in women with clinical complete response to neoadjuvant chemotherapy in breast carcinoma

Oncology Jul 25, 2018

Resende U, et al. - In this retrospective study, researchers intended to explore predictors of pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast carcinoma that also presented clinical complete response (cCR) evaluated in breast, axilla and breast and axilla. Participants in the study were 310 women with breast carcinoma who received NAC from January 1, 2013 to December 31, 2015 with follow-up until August 31, 2016. The main independent predictors of pCR in women who also had cCR to NAC in breast and breast and axilla were triple negative subtype and HER2-positive, but none was predictor in axilla. Findings revealed that the independent predictor of cCR in breast and breast and axilla was the Ki67 ≥50%.

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