Bainey KR, Fleg JL, Hochman JS, et al. - The extent of coronary artery disease (CAD) predicted death or myocardial infarction (D/MI) among ISCHEMIA-CKD (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches–Chronic Kidney Disease) candidates randomized to the invasive strategy, whereas severity of ischemia did not.

• Participants who were randomly assigned to invasive management and had available data on coronary angiography and stress testing were included in the study.

• Three hundred seven of the 388 participants had complete coronary angiography and stress testing data.

• D/MI occurred in 104/307 candidates (33.9%).

• The extent of CAD was linked to an elevated risk of D/MI, although the severity of the ischemia was not. Such associations remained following multivariable adjustment.

• The adjusted hazard ratio (HR) for 1VD was 1.86 using 0-vessel disease as reference.

• The HR for severe ischemia was 0.84 using moderate ischemia as the reference.