Tsyganenko D, et al. - Given a possible utility of extracorporeal life support (ECLS) as a bridge to diagnosis and decision-making for further treatment with long-term left ventricular assist devices (LVADs), researchers sought to develop an algorithm to predict outcomes for a rational use of long-term ventricular assist device therapy. ECLS was provided to 714 adult patients in their institution from January 2012 to January 2018. During the same period, LVAD was implanted in 618 patients. Of these, 100 patients were further supported with a long-term LVAD. Penalized multivariable logistic regression analysis of the datasets of these 100 consecutive patients suggest following as the 1-year mortality predictors: bilirubin increase per mg/dl, C-reactive protein increase per mg/dl, BMI >30 kg/m² and female gender. These data were the basis for creating a nomogram estimating 1-year mortality after LVAD implantation. As per findings, patients experiencing cardiogenic shock could undergo LVAD implantation following stabilization using ECLS, with elevated mortality in an otherwise futile situation. The risk for mid-term mortality increase in correlation to liver dysfunction, inflammatory status and obesity.