Hoenigl M, et al. - Considering the randomized trials documenting the efficacy of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men, researchers conducted this follow-up study of the TAPIR randomized controlled multicenter PrEP trial focusing on the challenges faced by participants regarding acquiring PrEP on their own and remaining adherent. Completion of ≥1 posttrial visit in addition to adequate adherence was reported for more than half of PrEP users. Less problematic substance use, higher risk behavior, and adequate adherence in year 1 of TAPIR were the significant predictors of adequate adherence posttrial.