Kaboré JL, et al. - Researchers sought to determine the characteristics of individuals who may most likely benefit from long‐term opioid therapy with regard to reduction in pain severity and improved mental health‐related quality of life (mQoL) without considering potential risks. In this retrospective cohort study of 116 patients (age = 51.3 ±12.5 years, male = 42.2%), patient enrollment was done from the Quebec Pain Registry between 2008 and 2011; these patients had initiated opioid therapy after their first appointment in a multidisciplinary pain clinic and persisted with this treatment for at least 12 months. They identified reporting of clinically significant reduction in pain severity in 26.7% of patients while 20.2% of patients reported improvement in mQoL on long‐term opioid therapy. The analysis yielded no clinically meaningful predictors of opioid therapy effectiveness making it tough to inform clinicians about which CNCP patients are most likely to benefit from long‐term opioid therapy.