Hu J, et al. - Researchers analyzed studies defining predictors of inguinal lymph node metastasis in penile cancer, via this meta-analysis. The included studies were identified from the PubMed, Embase, and Cochrane Library databases. Including 4,802 patients, 42 eligible studies were analyzed. Tumor-associated biomarkers and invasive clinicopathologic features were the two categories of predictors identified. Program death ligand 1 overexpression, higher neutrophil-to-lymphocyte ratio, higher C-reactive protein, squamous cell carcinoma antigen overexpression, and P53 protein overexpression were all documented as biomarker-specific predictors. Positive clinical lymph node, high-risk histopathological subtype, intermediate-risk subtype, vertical growth pattern, higher stage, higher tumor grade, tumor size (>3 cm), LVI, invasion depth (>5 mm), nerve invasion, corpora cavernosum invasion, corpus spongiosum invasion and urethra invasion were identified as clinicopathological predictors.