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Predictors of hypertensive disorders in pregnancy in women with and without polycystic ovary syndrome: The Australian Longitudinal Study of Women's Health

Clinical Endocrinology Mar 24, 2021

Khomami MB, Earnest A, Loxton D, et al. - Researchers herein examined how polycystic ovary syndrome (PCOS) affects the incidence of hypertensive disorders in pregnancy (HDP) via performing post hoc subgroup analyses of the Australian Longitudinal Study on Women's Health by level of risk. In this longitudinal study of a total of 14,247 participants, the inclusion criteria were met by 5,838 women. Age, BMI, country of birth, parity, multiple pregnancy, subfertility, infertility treatment (hormonal vs. in vitro fertilization), gestational diabetes (GDM), family history of GDM and socioeconomic status were the included risk factors. In a univariate model, there appeared a higher risk of HDP in correlation with PCOS, however, the significance of the correlation was not retained after adjustment for risk factors. However, in multivariate analysis of subgroups, the correlation of PCOS with higher risk of HDP remained significant in non‐obese women only.

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