Yap YS, et al. - Researchers performed a comparison of the incidence and time to onset of grade 2 or greater hand-foot syndrome (HFS) in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS. In this work, the onset of grade 2 or higher HFS was not significantly prevented or delayed with pyridoxine. They identified serum and red blood cell folate levels as independent predictors of HFS.