Poirier D, Gervais P, Fuchs M, et al. - Given a risk of developing Clostridioides difficile infection (CDI) among asymptomatic patients colonized with C difficile, researchers sought the predictors of hospital-onset CDI (HO-CDI) among colonized patients. in addition, they investigated the potential benefits of primary prophylaxis to prevent CDI. They screened 19,112 patients; among these, colonization was identified in 960 (5%) patients. The inclusion criteria were met by 513. Development of HO-CDI was reported in 39 (7.6%) cases, with a 30-day attributable mortality of 15%. Risks of HO-CDI were increased in significant independent correlation with an increasing length of stay, exposure to multiple classes of antibiotics, use of opioids, and cirrhosis, whereas a lower risk was observed in correlation with the use of laxatives. The greatest risk of HO-CD was observed in correlation with receiving B-lactam with B-lactamase inhibitors, first-generation cephalosporins, and carbapenems among the antimicrobials. By contrast, significant predictors of HO-CDI were patient age, the use of proton pump inhibitors, and the use of primary prophylaxis.