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Predictors of biliary strictures after liver transplantation among recipients of DCD (donation after cardiac death) grafts

Digestive Diseases and Sciences Jan 08, 2019

Kohli DR, et al. – In this study, researchers assessed risk factors potentially linked to the development of biliary strictures in donation after cardiac death liver transplantation (DCD LT) recipients. Study participants included 100 DCD LT recipients who underwent transplantation from 2012 to 2017 and were divided into two groups: those with anastomotic or non-anastomotic biliary strictures who required endoscopic retrograde cholangiopancreatography (ERCP; “stricture group”) and those who did not require ERCP or had cholangiograms without evidence of biliary strictures (“non-stricture group”). Of the DCD LT recipients, 49 underwent ERCP. The researchers noted the frequent occurrence of biliary strictures in DCD LT recipients. The biliary strictures seemed to have a possible relation to older age of donor. Predictors for subsequent development of biliary strictures comprised hyperbilirubinemia immediately after transplant and higher INR in the first 7 days after transplant.

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