Visser LL, et al. - Researchers sought to compile current knowledge on prognostic factors for invasive disease following a diagnosis of ductal carcinoma in situ (DCIS). Via a systematic review with meta-analyses, they reviewed 1,781 articles; of these, inclusion criteria were met by 40 articles. The 6 statistically significant prognostic factors identified were African-American race, premenopausal status, detection by palpation, involved margins, high histologic grade, and high p16 expression.