Kolk MZH, van Veelen A, Agostoni P, et al. - Researchers assessed factors predictive of procedural success of percutaneous coronary intervention (PCI) of chronic total coronary occlusions (CTOs) in a non‐infarct‐related artery post-ST‐segment elevation myocardial infarction (STEMI). They also focused on the impact on left ventricular functionality (LVF), infarct size, and pro‐arrhythmic electrocardiogram (ECG) parameters. This investigation represents a subanalysis of the EXPLORE trial, wherein 302 STEMI patients suffering from a concurrent CTO were randomly assigned to CTO PCI (n = 147) or no‐CTO PCI (NPCI, n = 154). For this subanalysis, patients were split into successful CTO PCI (SPCI, n = 106), failed CTO PCI (n = 41), and no‐CTO PCI (n = 154) groups. Findings of this subanalysis revealed that CTO PCI failure was independently predicted by a CTO lesion length >20 mm, whereas there were no adverse impacts of procedural failure on LVF or pro‐arrhythmic ECG parameters.