Tasar O, et al. - Via this retrospective analysis of 3205 patients (824 females, mean age: 58.6 years) who underwent primary percutaneous coronary intervention, researchers investigated the predictors of angiographic no-reflow development as well as the long-term (median follow-up time=59 months) clinical endpoints. Angiographic no-reflow [final Thrombolysis In Myocardial Infarction (TIMI)<3 flow] and reflow (final TIMI 3) groups were defined, including 324 and 2881 patients, respectively. The identified predictors that were significant, included age, Killip class≥2, pain-to-balloon time more than 4 h, baseline TIMI≤1 flow, lesion length of at least 15 mm, reference vessel diameter of at least 3.5 mm, cutoff occlusion pattern, and SYNTAX score of at least 19. Both in-hospital and long-term very high morbidity and mortality rates were reported in relation to the development of no-reflow.