Predictors and outcomes of coronary artery bypass grafting: A systematic and untargeted analysis of > 120,000 individuals and > 1,300 disease traits
Journal of Cardiothoracic and Vascular Anesthesia Mar 31, 2021
Aittokallio J, Kauko A, Palmu J, et al. - Researchers investigated the correlates and outcomes of coronary artery bypass grafting (CABG) via performing an untargeted data-driven analysis. From nationwide healthcare registers, information was retrieved on up to 1,327 disease traits preceding and following CABG. They assessed a patient sample of 127,911 people including 3,784 CABG patients. The correlation was assessed between 1) traits and incident CABG and 2) CABG and incident traits using multivariable-adjusted Cox models. A 12.2-fold risk of dying was observed for CABG patients in the fourth quartile of a risk score based on the top predictors of mortality when compared with those in the first quartile. Per findings, known CVD risk factors exhibit the strongest correlation with incident CABG. However, there was correlation of CABG with raised risk of several somewhat unexpected non-CVD traits, including anemia, gastrointestinal disorders, acute renal failure, septicemia, lung cancer, Alzheimer's disease, and COPD.
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