Setia N, et al. - Four hundred eighty-six gastric carcinomas which had been grouped into protein expression-based groups were involved in this case study in order to examine the predictive value of morphology for biomarker expression and its connection with protein expression-based classification of gastric carcinoma. For maximizing the positive predictive values, WHO patterns could be used. These incorporate PD-L1 testing in tubular, carcinoma with lymphoid stroma, undifferentiated and poorly cohesive patterns and Her2/neu testing in tubular, mixed, papillary, mucinous and solid patterns. Thus, to choose people for personalized therapy, the predictive values and morphologic relationships exhibited here have the potential.