Zhang S, et al. - A meta-analysis was conducted of patients who underwent percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI) to determine the predictive ability of neutrophil to lymphocyte ratio (NLR) for in-hospital and long-term prognosis in this group of patients. NLR was shown to be a predictor of hospitalization and long-term prognosis in patients with STEMI after PCI.

Methods

• Researchers collected studies associated with the prognosis of NLR and STEMI patients published in the Pubmed, Embase, and Ovid databases before June 2017.
• They extracted the relevant data and performed meta-analysis using Review Manager Version 5.3.

Results

• Analysis included 14 studies with 10,245 patients with STEMI after PCI.
• Findings demonstrated significant difference for the following: mortality (P < 0.001; relative risk (RR) 3.32; 95% confidence interval (CI) 2.45–4.49), hospital cardiac mortality(P < 0.001; RR 3.22; 95% CI 2.25–4.60), all mortality (P < 0.001; RR 3.23; 95% CI 2.28–4.57), major adverse cardiovascular events (MACE) (P < 0.001; RR 2.00; 95% CI 1.62–2.46), in-stent thrombosis (P < 0.001; RR 2.72 95% CI 1.66–4.44), nonfatal myocardial infarction(MI) (P < 0.001; RR 1.93; 95%CI 1.43–2.61), angina (P=0.007; RR 1.67; 95%CI 1.15–2.41), advanced heart failure (AHF) (P < 0.001; RR 1.81; 95% CI 1.48–2.21), arrhythmia (P=0.002; RR 1.38; 95% CI 1.13–1.69), no reflow (P < 0.001; RR 2.28; 95% CI 1.46–3.57), long-term all mortality (P < 0.001; RR 3.82; 95% CI 2.94–4.96), cardiac mortality (P=0.004; RR 3.02; 95% CI 1.41–6.45), MACE (P < 0.001; RR 2.49; 95% CI 1.47–4.23), and nonfatal MI (P=0.46; RR 1.32; 95% CI 0.63–2.75).