Mazzoni M, Pistorio A, Magnaguagno F, et al. - This study was intended to characterize the prevalence of MRI subclinical synovitis in a large cohort of juvenile idiopathic arthritis (JIA) patients in clinical remission and to evaluate its predictive value in terms of disease flare and joint deterioration. Researchers retrospectively included 90 patients with clinically inactive JIA who had undergone a contrast-enhanced MRI of a previously affected joint. They evaluated baseline and follow-up radiographs to assess structural damage progression. Despite clinical remission, MRI-detected subclinical inflammation was present in a large proportion of patients with JIA. The outcomes demonstrated that subclinical synovitis and bone marrow edema have been shown to play a role in predicting the risk of disease relapse and joint deterioration, with potential implications for patient management.