Peng S, et al. - To evaluate the prognostic significance of the primary tumor cytokine mRNA levels and underlying mechanisms in hepatocellular carcinoma (HCC), researchers used database analysis, clinical pathological studies, and in vitro biological experiments on human hepatic cancer cell lines. Promotion of migration and invasion of Huh-7 and HepG2 cells due to IL-8 was observed in wound healing, transwell, and western blotting assay results. They recorded the induction of EMT of HCC cells through the IL-8/ERK1/2/SNAI1 and IL-8/STAT3/TWIST1 signaling pathways.